Therapeutic targeting and transcriptional subtyping of pancreatic ductal adenocarcinoma
Therapeutic targeting and therapy resistance of pancreatic cancer
Colorectcal cancer research
I studied medicine between 2006-2012 at the University of Regensburg and at the University of Leipzig and did my MD-Thesis (Dr. med.) on the genetic background of chronic pancreatitis in the lab of Prof. Jonas Rosendahl at the University of Leipzig. In 2013, I started my residency as a clinical pathologist at the Institute of Pathology of the University of Heidelberg (Director: Prof. Dr. P. Schirmacher) and joined the lab of Prof. Wilko Weichert. Moving to the Institute of Pathology of the Technical University of Munich (Director: Prof. Dr. W. Weichert) in 2015, I finished my Habilitation in 2018 (Privatdozent/Associate Professor) and received my board certification as a full pathologist in 2019. In November 2017, I accepted the kind offer of Prof. Saur to associate my research to his lab as a postdoctoral researcher.
Short description of research field/project:
My principal research interest is the genetic background of colorectal neoplasias and especially colorectal cancer (CRC) and its specific morphologic subtypes, which I investigated using a morphomolecular approach in the lab of Prof. Weichert.
My current research in the Saur lab focuses on organoids as a tool to comparatively model colorectal neoplasias, with a focus on factors that influence the progression from various pre-malignant precursor lesions (adenomas) to invasive carcinoma or on the potential molecular background of specific CRC subtypes, such as mixed adenoneuroendocrine carcinoma or neuroendocrine carcinoma. My research is supported by the Else Kröner Fresenius Stiftung.
Publications:
Jesinghaus M, Brühl F, Steiger K, Klare P, Reiser M, Scheiter A, Konukiewitz B, Kuhn P, Münch S, Quante M, Schmid RM, Wilhelm D, Feith M, Friess H, Combs S, Saur D, Boxberg M, Weichert W.
Am J Surg Pathol. 2019
Appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoids are genetically distinct from primary colorectal-type adenocarcinomas of the appendix.
Jesinghaus M, Konukiewitz B, Foersch S, Stenzinger A, Steiger K, Muckenhuber A, Groß C, Mollenhauer M, Roth W, Dethlefsen S, Weichert W, Klöppel G, Pfarr N, Schlitter AM.
Mod Pathol. 2018
Introducing a Novel Highly Prognostic Grading Scheme Based on Tumor Budding and Cell Nest Size for Squamous Cell Carcinoma of the Uterine Cervix
Jesinghaus M, Strehl J, Boxberg M, Brühl F, Wenzel A, Konukiewitz B, Schlitter AM, Steiger K, Warth A, Schnelzer A, Kiechle M, Beckmann MW, Noske A, Hartmann A, Mehlhorn G, Koch MC, Weichert W
J Pathol: Clin Res. 2018
Jesinghaus M, Konukiewitz B, Keller G, Kloor M, Steiger K, Reiche M, Penzel R, Endris V, Arsenic R, Hermann G, Stenzinger A, Weichert W, Pfarr N, Klöppel G.
Mod Pathol. 2017
Jesinghaus M, Boxberg M, Konukiewitz B, Slotta-Huspenina J, Schlitter AM, Steiger K, Specht K, Wieczorek K, Warth A, Schmidt T, Hartmann A, Demir IE, Feith M, Ott K, Weichert W.
Am J Surg Pathol. 2017
Jesinghaus M, Steiger K, Slotta-Huspenina J, Drecoll E, Pfarr N, Meyer P, Konukiewitz B, Bettstetter M, Wieczorek K, Ott K, Feith M, Langer R, Weichert W, Specht K, Boxberg M.
Oncotarget. 2017
Genetic heterogeneity in synchronous colorectal cancers impacts genotyping approaches and therapeutic strategies.
Jesinghaus M, Pfarr N, Kloor M, Endris V, Tavernar L, Muckenhuber A, von Knebel Doeberitz M, Penzel R, Weichert W, Stenzinger A.
Genes Chromosomes Cancer. 2016
Genotyping of Colorectal Cancer for Cancer Precision Medicine: Results from the IPH Center for Molecular Pathology.
Jesinghaus M, Pfarr N, Endris V, Kloor M, Volckmar AL, Brandt R, Herpel E, Muckenhuber A, Lasitschka F, Schirmacher P, Penzel R, Weichert W, Stenzinger A.
Genes Chromosomes Cancer. 2016
Distinctive Spatiotemporal Stability of Somatic Mutations in Metastasized Microsatellite-stable Colorectal Cancer.
Jesinghaus M, Wolf T, Pfarr N, Muckenhuber A, Ahadova A, Warth A, Goeppert B, Sers C, Kloor M, Endris V, Stenzinger A, Weichert W.
Am J Surg Pathol. 2015.
Boxberg M1, Jesinghaus M1, Dorfner C, Mogler C, Drecoll E, Warth A, Steiger K, Bollwein C, Meyer P, Wolff KD, Kolk A, Weichert W.
Histopathology. 2017 1 shared
Pancreatic neuroendocrine carcinomas reveal a closer relationship to ductal
adenocarcinomas than to neuroendocrine tumors G3.
Konukiewitz B, Jesinghaus M1, Steiger K, Schlitter AM, Kasajima A, Sipos B, Zamboni G, Weichert W, Pfarr N, Klöppel G.
Hum Pathol. 20181 shared
Genetic analysis of heme oxygenase 1 (HMOX1) in different forms of pancreatitis.
Weis S1, Jesinghaus M1, Kovacs P, Schleinitz D, Schober R, Ruffert C, Herms M, Wittenburg H, Stumvoll M, Blüher M, Grützmann R, Schulz HU, Keim V, Mössner J, Bugert P, Witt H, Drenth JP, Krohn K, Rosendahl J.1 shared
PLoS One. 2012
Boxberg M, Kuhn PH, Reiser M, Erb A, Steiger K, Pickhard A, Straßen U, Koob I, Kolk A, Warth A, Jesinghaus M, Weichert W.
Am J Surg Pathol. 2018
Immunohistochemical expression of CD44 in oral squamous cell carcinoma in relation to histomorphologic parameters and clinicopathological factors.
Boxberg M, Götz C, Haidari S, Dorfner C, Jesinghaus M, Drecoll E, Boskov M, Wolff KD, Weichert W, Haller B, Kolk A.
Histopathology. 2018
Novel prognostic histopathological grading system in oral squamous cell carcinoma based on tumour budding and cell nest size shows high interobserver and intraobserver concordance.
Boxberg M, Bollwein C, Jöhrens K, Kuhn PH, Haller B, Steiger K, Wolff KD, Kolk A, Jesinghaus M, Weichert W.
J Clin Pathol. 2018
Composition and Clinical Impact of the Immunologic Tumor Microenvironment in Oral Squamous Cell Carcinoma.
Boxberg M, Leising L, Steiger K, Jesinghaus M, Alkhamas A, Mielke M, Pfarr N, Götz C, Wolff KD, Weichert W, Kolk A.
J Immunol. 2018
Kohlruss M, Reiche M, Jesinghaus M, Grosser B, Slotta-Huspenina J, Hapfelmeier A, Bauer L, Novotny A, Weichert W, Keller G
Scientific Reports. 2018
Pfarr N, Darb-Esfahani S, Leichsenring J, Taube E, Boxberg M, Braicu I, Jesinghaus M, Penzel R, Endris V, Noske A, Weichert W, Schirmacher P, Denkert C, Stenzinger A.
Genes Chromosomes Cancer. 2017
Fang HY, Münch NS, Schottelius M, Ingermann J, Liu H, Schauer M, Stangl S, Multhoff G, Steiger K, Gerngroß C, Jesinghaus M, Weichert W, Kühl AA, Sepulveda AR, Wester HJ, Wang TC, Quante M.
Clin Cancer Res. 2017
Schlitter AM, Jesinghaus M, Jäger C, Konukiewitz B, Muckenhuber A, Demir IE, Bahra M, Denkert C, Friess H, Kloeppel G, Ceyhan GO, Weichert W.
Eur J Cancer. 2017
Pharmacoproteomic characterisation of human colon and rectal cancer.
Frejno M, Zenezini Chiozzi R, Wilhelm M, Koch H, Zheng R, Klaeger S, Ruprecht B, Meng C, Kramer K, Jarzab A, Heinzlmeir S, Johnstone E, Domingo E, Kerr D, Jesinghaus M, Slotta-Huspenina J, Weichert W, Knapp S, Feller SM, Kuster B.
Mol Syst Biol. 2017
A novel pretherapeutic gene expression based risk score for treatment guidance in gastric cancer.
Bauer L, Hapfelmeier A, Blank S, Reiche M, Slotta-Huspenina J, Jesinghaus M, Novotny A, Schmidt T, Grosser B, Kohlruss M, Weichert W, Ott K, Keller G.
Ann Oncol. 2017
Muckenhuber A, Berger AK, Schlitter AM, Steiger K, Konukiewitz B, Trumpp A, Eils R, Werner J, Friess H, Esposito I, Klöppel G, Ceyhan GO, Jesinghaus M, Denkert C, Bahra M, Stenzinger A, Sprick MR, Jäger D, Springfeld C, Weichert W.
Clin Cancer Res. 2017
Distribution of MED12 mutations in fibroadenomas and phyllodes tumors of the breast--implications for tumor biology and pathological diagnosis.
Pfarr N, Kriegsmann M, Sinn P, Klauschen F, Endris V, Herpel E, Muckenhuber A, Jesinghaus M, Klosterhalfen B, Penzel R, Lennerz JK, Weichert W, Stenzinger A.
Genes Chromosomes Cancer. 2015
Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer.
Gunther S, Ostheimer C, Stangl S, Specht HM, Mozes P, Jesinghaus M, Vordermark D, Combs SE, Peltz F, Jung MP, Multhoff G.
Front Immunol. 2015
Profiling of cMET and HER Family Receptor Expression in Pancreatic Ductal Adenocarcinomas and Corresponding Lymph Node Metastasis to Assess Relevant Pathways for Targeted Therapies: Looking at the Soil Before Planting the Seed.
Muckenhuber A, Babitzki G, Thomas M, Hölzlwimmer G, Zajac M, Jesinghaus M, Bergmann F, Werner J, Stenzinger A, Weichert W.
Pancreas 2016
A common variant of PNPLA3 (p.I148M) is not associated with alcoholic chronic pancreatitis.
Rosendahl J, Tönjes A, Schleinitz D, Kovacs P, Wiegand J, Ruffert C, Jesinghaus M, Schober R, Herms M, Grützmann R, Schulz HU, Stickel F, Werner J, Bugert P, Blüher M, Stumvoll M, Böhm S, Berg T, Wittenburg H, Mössner J, te Morsche R, Derikx M, Keim V, Witt H, Drenth JP.
PLoS One. 2012
Konukiewitz B, Schlitter AM, Jesinghaus M, Pfister D, Steiger K, Segler A, Agaimy A, Sipos B, Zamboni G, Weichert W, Esposito I, Pfarr N, Klöppel G.
Mod Pathol. 2017
Pfarr N, Penzel R, Klauschen F, Heim D, Brandt R, Kazdal D, Jesinghaus M, Herpel E, Schirmacher P, Warth A, Weichert W, Endris V, Stenzinger A.
Genes Chromosomes Cancer. 2016
Multi-modal spatial-omics analysis
(i.e. histology whole slide images & spatial transcriptomics). Integrating spatial gene expression and pancreatic tumour morphology (multi-modal spatial-omics analysis) to predict tumour subtypes and therapeutic vulnerabilities
I am a first year PhD Candidate at Saur Lab (TranslaTUM), Peng Lab (Helmholtz Munich). Before joining as a doctoral candidate, I was a researcher at Boston University, School of Medicine (BUSM), USA, working on developing image biomarkers of lung squamous premalignant progression. I got my master’s degree in computer science from Rutgers University, USA. My master’s thesis involved developing methods for automatic cardiac segmentation using multi-modal data. My research interests are specifically focused towards deep learning and medical image analysis. I aim to become a research scientist bridging the gap between state of the art academic research and it’s huge translational potential in biomedical industry.
KRAS-dependency and heterogeneity in PDAC
I completed my BSc studies in Microbiology at the University of Ljubljana, Slovenia, in 2018, and afterwards MSc in Genetics and molecular biosciences at the University of Helsinki, Finland, in 2020. I continued my research for one year at the National Institute of Chemistry, Slovenia, where I worked in the field of immunology and synthetic biology. Since 2021 I am a PhD student in Saur lab, where I am investigating KRAS dependency and heterogeneity of PDAC tumors, using transgenic mouse models.
Tumor microenvironment in pancreatic ductal adenocarcinoma
Single-cell RNA sequencing
